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In this brief, readable, and revealing book, one of the pioneers of the now rapidly evolving field of DNA repair traces the history of the discovery of the more important mechanisms by which cells respond to DNA damage. Errol Friedberg has written an enjoyable and informative introduction to the study of DNA mutagenesis and re-pair that will interest students at an advanced undergraduate or graduate student level as well as investigators in fields as diverse as oncogenesis, cell cycle regulation, transcription and DNA replication.

Based on machinery bacteria use to target foreign nucleic acids, these powerful techniques allow investigators to edit nucleic acids and modulate gene expression more rapidly and accurately than ever before. Featuring contributions from leading figures in the CRISPR-Cas field, this laboratory manual presents a state-of-the-art guide to the technology.

It includes step-by-step protocols for applying CRISPR-Cas-based techniques in various systems, including yeast, zebrafish, Drosophila, mice, and cultured cells e. The contributors cover web-based tools and approaches for designing guide RNAs that precisely target genes of interest, methods for preparing and delivering CRISPR-Cas reagents into cells, and ways to screen for cells that harbor the desired genetic changes.

The book is thus an essential laboratory resource for all cell, molecular, and developmental biologists, as well as biochemists, geneticists, and all who seek to expand their biotechnology toolkits. These and hundreds of other important advances in biology were announced, debated, and distilled at the Cold Spring Harbor Symposia. These meetings, held each year on tranquil grounds of one of the world's leading research institutes, have been notable events in biomedical research since Now this essential archive, dating from to , is going online. Cystic fibrosis is caused by mutations in the CFTR gene, which encodes an ion channel protein that regulates anion movement across the epithelial membranes of the lungs, pancreas, and other organs.

In cystic fibrosis patients, anion transport is impeded, causing sticky, viscous mucus to build up and clog these vital organs. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides an in-depth examination of cystic fibrosis biology and treatment strategies. Contributors examine the structure and dynamics of CFTR, its normal physiological roles in the airway and digestive epithelia, and how those operations are impaired in patients with cystic fibrosis.

The numerous CFTR mutations and how they alter the expression, synthesis, processing, and function of CFTR in cystic fibrosis and other CFTR-related disorders are considered, as are disease-modifying genes that influence disease severity. This volume includes discussions of therapy and treatment strategies for cystic fibrosis, ranging from airway clearance techniques and pancreatic enzyme replacements to the modulation of CFTR and related ion transport pathways. It will be an essential reference for molecular and cellular biologists, physiologists, and clinicians interested in understanding the biological basis of the disease and the search for effective therapies.

Cytokines e. They are important regulators of the immune system, helping to control lymphocyte development and function, orchestrate inflammation, and defeat microbial and viral invaders. But they also play important roles in the nervous system, embryonic development, and diseases such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the spectrum of cytokines that are produced and their roles in normal physiology and disease. The contributors examine the numerous cytokines and their cognate receptors, the downstream signaling mechanisms e.

These molecular interactions are discussed in the context of their physiological effects; the roles of cytokines in the development and activities of the immune system are emphasized. The authors also explore how the actions of cytokines may be modulated for treating patients with autoimmune disorders, immunodeficiency, infections, allergies, and cancer. Thus, this volume is an indispensable reference not only for cell biologists and immunologists but for all who are interested in targeting cytokine signaling for therapeutic purposes. The cytoskeleton is the intracellular filament system that controls the morphology of a cell, allows it to move, and provides trafficking routes for intracellular transport.

This textbook presents a comprehensive and up-to-date view of the cytoskeleton, cataloguing its many different components and explaining how they are functionally integrated in different cellular processes. It starts by laying out the basic molecular hardware, before describing in detail how these components are assembled in cells and linked to neighboring cells and the extracellular matrix to maintain tissue architecture.

It then surveys the roles of the cytoskeleton in processes such as intracellular transport, cell motility, signal transduction, and cell division. The book is thus essential reading for students learning about intracellular structure.

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It also represents a vital reference for all cell and developmental biologists working in this field. In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. The science of gene function has a vocabulary of specialized, sometimes confusing terms to explain how traits and diseases are inherited, how genes are organized and regulated in the genome, and how the genetic code is read and translated by cells.

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These terms are often a barrier to full understanding of the underlying concepts. Yet, as more and more individuals learn about their genomes, the information these sequences contain cannot be understood or explained without reference to the basic ideas of genetics. Botstein draws on his long experience as a teacher and pioneering scientist to explain and illuminate what many genetic terms mean and how they entered common usage.

The idea of human gene therapy was accepted by the medical community and society at large long before believable clinical benefits began to emerge. In this book, some of the field's most distinguished contributors chronicle the evolution of this momentous direction for medicine, illustrating how imaginative concepts shaped the development of technologies and brought the daring new idea to its current position of imminent practical success.

This is a book designed to endure as clinical advances accumulate, a clear-eyed work of reference that will anchor the further development of this revolution in therapy. It is an essential addition to libraries of clinical medicine, biotechnology, and public policy, and a resource that no laboratory investigator with an interest in the biology of gene transfer should be without.

Cell and molecular biology are becoming increasingly data driven. Technological advances and increased computing power mean that researchers now increasingly quantify experimental results, rather than simply report qualitative, representative observations. The Digital Cell provides a comprehensive guide for scientists seeking to make this transition. It describes how data should be generated and processed, discussing research workflows, pipelines, and storage solutions.

The book examines the wide variety of statistical approaches that can be used for data analysis, emphasizing concepts such as significance and reproducibility. It also includes an introduction to coding, including examples of how to write and use R scripts to analyze results.

In addition, there is useful advice on how to plot and present data to convey results most effectively. The structure of DNA proposed by James Watson and Francis Crick in was one of the most important scientific discoveries of the twentieth century, transforming biology, giving medicine new impetus, and providing a foundation for the new industry of biotechnology.

Jim Watson's best-selling memoir of the events leading to this discovery, The Double Helix, has enthralled millions of readers since its publication in Watson retraces those events in a very personal reminiscence of the period and the people involved. This is an account of one of the great dramas of science, told from the intimate perspective of a participant who, aged 25 at the time of the discovery, has become one of the intellectual leaders of our time. James D. DNA Interactive DNAi is a multimedia resource for high school and introductory college biology that shows how we came to understand the language of DNA, how we bend it to our own service, and what it can tell us about who we are.

Homologous recombination involves the precise exchange of similar or identical nucleic acid sequences between two DNA molecules. This process directs the repair of many DNA lesions in somatic cells and generates genetic variation in sperm and egg cells during meiosis. It is a nearly universal biological process that is conserved from phage to humans. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of recombinational DNA repair, meiotic recombination, and the regulation of these processes.

The contributors examine the dozens of proteins that are involved in recombinational repair and the various pathways in which they are employed e. They also discuss how these proteins and pathways are strictly regulated to avoid genomic instability, which can lead to diseases such as cancer, and how they are coordinated with other nuclear processes e. Meiotic recombination, the characteristics that distinguish it from recombinational repair, and effects of its dysregulation e. This volume is an indispensable reference for biochemists, molecular biologists, and cell biologists who want to understand how DNA recombination maintains genomic integrity in individual organisms and across generations.

DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass this genetic material on to their descendants. DNA replication involves the coordinated interplay and regulation of many complex protein assemblies during the various stages of cell division. When these processes go awry, cancer and other diseases can ensue.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of DNA replication and its control across all domains of life. The contributors examine the molecular machinery involved in the assembly of replication origin complexes, the establishment of replication forks, unzipping of the double helix, priming of DNA synthesis, and elongation of daughter strands.

Chromatin organization and dynamics, lagging-strand maturation, telomere replication, and mechanisms to handle errors and damage in DNA are also discussed. Including examination of the complex interactions between the core replication machinery and the regulatory circuits that drive cell cycle progression, this volume is an indispensable reference for not only biochemists and molecular biologists, but also cell biologists and all who want to understand this fundamental process of life. Proven through more than 10 years of teaching at research and nonresearch colleges and universities, junior colleges, community colleges, and advanced biology programs in high school, this book has been successfully integrated into introductory biology, general biology, genetics, microbiology, cell biology, molecular genetics, and molecular biology courses.

The first eight chapters have been completely revised, extensively rewritten, and updated. The new coverage extends to the completion of the draft sequence of the human genome and the enormous impact these and other sequence data are having on medicine, research, and our view of human evolution. All sections on the concepts and techniques of molecular biology have been updated to reflect the current state of laboratory research. The laboratory experiments cover basic techniques of gene isolation and analysis, honed by over 10 years of classroom use to be thoroughly reliable, even in the hands of teachers and students with no prior experience.

Extensive prelab notes at the beginning of each experiment explain how to schedule and prepare, while flow charts and icons make the protocols easy to follow. The answer is in DNA -- the stuff that genes are made of. Based on a song written by Joel Herskowitz while he was in medical school, the "Double Talking Helix Blues" is a book and audio presentation on the structure and function of DNA. The book includes the text for Joel's song, which is illustrated with spectacular paintings by Judy Cuddihy to provide an important visual component to the overall "lesson" on DNA.

This is followed by a guide written by Ira Herskowitz to explain the scientific terms and concepts in the song; this section describes in clear terms what, for example, a chromosome, nucleus, and molecule are. Accompanying the book is an audio performances of the song by Joel and Ira. Click here to listen, or right-click to download the MP3 file now! All in all, the "Double Talking Helix Blues" provides young readers with a wonderful introduction to concepts of cells and molecules, reproduction at the molecular level, and DNA and its structure.

The target age group for this presentation is ages 8 and up, as well as teachers, scientists, and all those interested in molecular biology at its most basic level. This exceptional laboratory manual describes thirty-seven procedures most likely to be used in the next decade for molecular, biochemical, and cellular studies on Drosophila. They were selected after extensive consultation with the research community and rigorously edited for clarity, uniformity, and conciseness.

The outstanding features of this protocol collection are: Scope: The methods included permit investigation of chromosomes, cell biology, molecular biology, genomes, biochemistry, and development. Depth: Each protocol includes the basic information needed by novices, with sufficient detail to be valuable to experienced investigators. Format: Each method is carefully introduced and illustrated with figures, tables, illustrations, and examples of the data obtainable.

Added value: The book's appendices include key aspects of Drosophila biology, essential solutions, buffers, and recipes. An evolution of Michael Ashburner's classic Drosophila: A Laboratory Manual, this book is an essential addition to the personal library of Drosophila investigators and an incomparable resource for other research groups with goals likely to require fly-based technical approaches. Barbara McClintock was born in , within a few years of the rediscovery of Mendel's laws.

Her life, discoveries, and insights span the history of genetics in this century. In the s, she became a dominant figure in the group that flourished at Cornell University under R. Emerson and made remarkable technical and conceptual advances in maize cytogenetics. McClintock's unique ability to discern relationships between the behavior of chromosomes and the properties of the whole organism earned her early recognition. She was elected to the National Academy of Sciences in and to the presidency of the Genetics Society of America in Had she done no more, McClintock would have become a major figure in the history of genetics.

But at Cold Spring Harbor, she began the studies of the consequence of dicentric chromosome formation and breakage that led her to the discovery of genetic elements capable of moving within the genome and controlling expression of other genes. Although McClintock was universally respected and admired, the first reaction to these findings was often uncomprehending or indifferent, even dismissive. In due course, however, the generality of mobile genetic elements and the concept of a dynamic genome were understood and widely accepted, culminating in the award to McClintock of an unshared Nobel Prize in As Barbara's 90th birthday approached, some of her many friends and colleagues were invited to write essays for the occasion.

This book contains a kaleidoscope of contributions, many by those who discovered transposition in other organisms. Their essays give a remarkable account of the scientific legacy of one of the century's greatest geneticists. Yeast genetics began with Winge's studies of S. Genetic studies in S. Within four decades, not without controversies, both yeast species were recognized as essential models in eukaryotic molecular cell biology. In this remarkable volume, Hall and Linder have assembled the reminiscences of many early investigators whose pioneering studies in the years before brought yeast biology to its current maturity.

These illustrated essays about the science, the events and the personalities involved capture a fascinating era, in the informal style made famous by Phage and the Origins of Molecular Biology. This is a book that all scientists interested in the development of modern genetics and molecular biology should have on their shelves. Amphibian embryos are supremely valuable in studies of early vertebrate development because they are large, handle easily, and can be obtained at many interesting stages.

And of all the amphibians available for study, the most valuable is Xenopus laevis, which is easy to keep and ovulates at any time of year in response to simple hormone injections. Xenopus embryos have been studied for years but this is a particularly exciting time for the field. Techniques have become available very recently that permit a previously impossible degree of manipulation of gene expression in intact embryos, as well as the ability to visualize the results of such manipulation.

This manual contains a comprehensive collection of protocols for the study of early development in Xenopus embryos. As a result it contains pointers, hints, and other technical knowledge not readily available elsewhere. This volume is essential reading for all investigators interested in the developmental and cell biology of Xenopus and vertebrates generally. Many of the techniques described here are illustrated in an accompanying set of videotapes which are cross-referenced to the appropriate section of the manual. In this classic book, the distinguished science writer Horace Freeland Judson tells the story of the birth and early development of molecular biology in the US, the UK, and France.

The fascinating story of the golden period from the revelation of the double helix of DNA to the cracking of the genetic code and first glimpses of gene regulation is told largely in the words of the main players, all of whom Judson interviewed extensively. The result is a book widely regarded as the best history of recent biological science yet published. This commemorative edition, honoring the memory of the author who died in , contains essays by his daughter Olivia Judson, Matthew Meselson, and Mark Ptashne and an obituary by Jason Pontin.

It contains all the content added to previous editions, including essays on some of the principal historical figures involved, such as Rosalind Franklin, and a sketch of the further development of molecular biology in the era of recombinant DNA. During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells.

Pathogens e. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all of the major pathways of endocytosis and postendocytic trafficking and how they regulate cellular and organismal physiology. They review the numerous machineries e. Topics such as lysosomal dynamics, the biophysical challenges of bending membranes, and the evolution of endocytic systems are also covered.

This volume also includes substantial discussion of the roles of endocytic trafficking in organismal development, physiology, and disease. It is thus an indispensable reference for cell biologists, but also for neuroscientists, immunologists, developmental biologists, microbiologists, and others concerned with the physiological and therapeutic implications of this key cellular process.

The endoplasmic reticulum ER is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other organelles, playing essential roles in cell growth and homeostasis. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of ER morphology and function, as well as its interactions with the nucleus, Golgi, and mitochondria.

Contributors examine how proteins translocate across the ER membrane, the processes that occur inside the ER lumen e. They also review quality-control mechanisms that are employed by the ER to detect and eliminate misfolded or unassembled proteins. Lipid synthesis and transport are also discussed. This volume covers not only the biochemistry and cell biology of the ER, but also ER stress, metabolism, and the role of the ER in viral replication.

Molecular Cloning: A Laboratory Manual, Third Edition, v. 1

Thus, it is an essential reference for cell biologists, physiologists, and pathologists interested in understanding the numerous functions of the ER. Agriculture plays a vital role supporting human life on Earth but faces significant challenges to feed the growing population. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the molecular bases of plant traits and addresses how this knowledge can be used to develop crops that are resilient to a changing environment.

The contributors review recent advances in our understanding of plant plasticity, circadian rhythms, stomatal development, inflorescence architecture, symbiotic phosphate acquisition, and specialized plant metabolism and discuss how this knowledge might be used to boost yields, improve tolerance to pathogens and environmental stress, and enhance nutritional content. The book also discusses the development and socioeconomic impact of deployment of genetically improved submergence-tolerant rice. This volume is therefore an essential read for all plant biologists, geneticists, and engineers interested in addressing agricultural and environmental challenges.

Beneath your skin there is an amazing hidden world of living cells. Millions and millions of cells work together, to make everything that is you. But did you know that you started life as just one tiny cell? And did you know that everything that lives on Planet Earth is also made of these amazing cells? Color and learn!

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Each coloring book incorporates all of the original text and artwork from the best-selling Enjoy Your Cells series, now in a delightfully enlarged format suitable for coloring book fans of all ages. The pages are brimming with dozens of drawings of cells, proteins, and DNA, accompanied by easy-to-understand but scientifically accurate commentary. Proceeds from the books help to support research and education at the world-renowned Cold Spring Harbor Laboratory. With exuberant graphics ranging from simple to intricate, these books are sure to bring hours of educational enjoyment to budding and experienced scientists alike!

Once again, they use their unique brand of simple but scientifically accurate commentary and exuberant graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA.

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This four-volume set includes all of the coloring books in the series, bundled together with a box of premium quality, pre-sharpened colored pencils, and a colorful sheet of water-resistant stickers inspired by the series pencils and stickers available while supplies last. It's the perfect gift for the scientist of any age! Recommended for ages 7 and up. Once again, they use their unique brand of simple but scientifically accurate commentary and exuberantly colorful graphics to take young readers on an entertaining exploration of the amazing, hidden world of cells, proteins, and DNA.

It's over ten years since Fran and Mic invented a new way of getting science across to children. With these books, children will learn to enjoy their cells and current affairs at the same time. And they're getting information that has been written and reviewed by working scientists, so it's completely correct and up-to-date. This series is a must for all elementary school students and those who care about educating them to be well-informed in a world of increasingly complex health-related and environmental issues.

Mic Rolph is a graphic designer with much television and publishing experience. These viruses, which include the hepatitis A and E viruses HAV and HEV, respectively , infect millions of individuals worldwide and pose significant threats to public health. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines recent progress in our understanding of the biology and pathogenic mechanisms of HAV and HEV, as well as prospects for improving their control.

Contributors explore the molecular characteristics and life cycles of HAV and HEV, their interactions with the liver and immune system, the clinical manifestations of the infections they cause, and their transmission via contaminated food and water. Additional topics include the geographic distributions of the various HAV and HEV genotypes, factors that influence their changing epidemiology, and the development of effective vaccines and vaccination strategies.

The authors also discuss advances in cell-culture systems and animal models, as well as how studies of HAV and HEV may provide insight into other viruses and infectious diseases of the liver. This volume is therefore an essential reference for all virologists, immunologists, pathologists, clinicians, and public health professionals. In many biological processes the regulation of gene expression involves epigenetic mechanisms. In this new edition of Epigenetics, 36 chapters written by experts in the field introduce and explain epigenetic effects from many perspectives.

These include the varied molecular mechanisms underpinning epigenetic regulation, discussion of cellular processes that rely on this kind of regulation, and surveys of model organisms in which epigenetic effects have been most studied. The original chapters have all been rewritten and brand new chapters cover topics such as the structure, function, and dynamics of histone-modifying enzymes and histone-interacting proteins. Other chapters address chromatin remodeling, DNA methylation, siRNAs, and gene silencing; X-chromosome inactivation, dosage compensation, and imprinting; and epigenetics in microbes, plants, insects, and mammals.

How epigenetic mechanisms act in cell division and cell type specification, and how errors in these pathways contribute to cancer and other human diseases are also considered, along with the importance of epigenetics for induced pluripotency and reprogramming. In addition, new chapters describe the involvement of epigenetic processes in epigenetic inheritance, neuronal development, metabolism and signaling, responses to the environment, and long-range chromatin interactions.

A series of short essays highlight important recent discoveries. All the chapters provide conceptual illustrations that help readers understand epigenetic control. The book is thus a benchmark text for advanced undergraduate and graduate courses on gene regulation, as well as an essential resource for scientists interested in this rapidly moving field. Epilepsy is due to abnormal signaling of neurons in the brain that can cause seizures.

The seizures are difficult to predict and, in a significant fraction of patients, refractory to current medical interventions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine includes contributions covering all aspects of epilepsy, its causes, pathophysiology, clinical characteristics, comorbidities, and treatment. Contributors discuss the genetic, developmental, and environmental triggers of recurrent seizures; molecular changes e.

Clinical aspects of the disease diagnosis, classification, and treatments are reviewed, as are common comorbidities e. Recent advances in drug development and surgical techniques aimed at reducing the morbidity and mortality of patients with epilepsy are also described. The authors highlight current challenges in the field of epilepsy, with the goal of assisting others in formulating relevant research questions.

This volume is therefore a vital reference not only for scientists and clinicians currently working in the field, but for all neuroscientists seeking to explore new research directions. Defined in the broadest sense, glycobiology is the study of the structure, biosynthesis, biology, and evolution of saccharides sugar chains or glycans that are widely distributed in nature in all living life forms.

Glycobiology is now one of the more rapidly growing fields in the natural sciences, with broad relevance to many areas of basic research, biomedicine, and biotechnology. The field includes the chemistry of carbohydrates, the enzymology of glycan formation and degradation, the recognition of glycans by specific proteins, roles of glycans in complex biological systems, and their analysis or manipulation by various techniques.

The third edition of this primary textbook in the field continues in the prior tradition, seeking to provide basic overview of glycobiology, directed towards the advanced undergraduate or the beginning graduate-level student of molecular and cellular biology and biomedicine. While efforts have been made to avoid a major increase in overall length of the text, substantial changes and improvements include the following:.

The comments of Nobel Laureates on the previous editions reflect the long-held belief that central functional roles played by the diversity of glycan chains would be revealed by research in this field. Now, as the result of advances in analytical chemistry and much deeper understanding of genomes, cell and tissue organization, this field has arrived. The third edition of Essentials of Glycobiology stands as the authoritative treatise on the subject, covering all aspects of the field and written by the world leaders in current research. Rothman, Nobel Laureate in Medicine, To do so is to avert one's gaze from an important part of life.

More than mere decoration, glycans magnify the diversity of the already diverse molecules to which they are attached, affect protein folding and stability, direct traffic within cells, serve as signposts of self vs. It is hard to imagine a world without complex sugars, but if such a world existed, it would be much diminished. The third edition of Essentials of Glycobiology may be life changing for scientists who have not yet engaged with glycobiology and will certainly be a treasured resource for those who already have.

In my field, structural biology, carbohydrate moieties in glycoproteins and in complex multi-component macromolecular systems have been and continue to be difficult to handle. I greatly welcome the effort made in this multiauthor volume to present results obtained with methods of structural biology in the context of the wealth of currently available chemical and biological data. I recommend the third edition of Essentials of Glycobiology as a highly useful reference on the current state of the field.

As the molecular revolution has unfolded, such science that relies on a reasonably direct correlation between genotype and phenotype has been relatively straightforward. Much more difficult to assess is the part played by glycosylation profiles in immune recognition and pathogen elimination. Perhaps even more intriguing is the issue of glycan abnormalities and recognition in cancer and many other disease processes.

Now, in a third edition of Essentials of Glycobiology written by authoritative leaders in the field, we learn how this knowledge has been rapidly advancing, and see possibilities for real breakthroughs in understanding and therapy. Doherty, Nobel Laureate in Medicine It reviews the latest advances in research into evolution, focusing on the molecular bases for evolutionary change.

The topics covered include the appearance of the first genetic material, the origins of cellular life, evolution and development, selection and adaptation, and genome evolution. Human origins, cognition, and cultural evolution are also covered, along with social interactions. The line-up of speakers comprised a stellar list of preeminent scientists and thinkers such as the zoologist and prolific author E. Wilson Harvard University ; Jack W.

A complete summary of the meeting can be found here. The effective design and analysis of experiments in biology are critical to success, yet graduate students in biological and medical sciences typically receive very little formal training in these steps. With feedback from readers of the first edition, colleagues, and students taking the very popular experimental design courses taught by the author, this second edition of Experimental Design for Biologists retains the engaging writing style while organizing the book around the four elements of experimental design: the framework, the system, the experiment, and the model.

The goal of every scientist is to discover something new and with the aid of Experimental Design for Biologists , this task is made a little easier. This handbook explains how to establish the framework for an experimental project, how to set up all of the components of an experimental system, design experiments within that system, determine and use the correct set of controls, and formulate models to test the veracity and resiliency of the data. This thoroughly updated edition of Experimental Design for Biologists is an essential source of theory and practical guidance for designing a research plan.

Andy O'Hara, a post-doctoral researcher in a London cancer research institute, agrees to help an attractive colleague, Gina, who is collaborating with a pharmaceutical company. She is working on a virus-based vaccine but has discovered the company is planning a clinical trial of the vaccine in Africa without preliminary animal tests. Andy gets a tip-off that Gina's corporate collaborator has a shady past, but also discovers a scientific reason why the vaccine may be doomed to failure.

As this excerpt begins, Andy and his friend Christine have helped Gina set up an illicit mouse experiment in their own animal facility, a move that could end all their careers if discovered. Read an excerpt here. The drawings are by the renowned Australian artist, Lewis Miller. Each is accompanied by an essay on the accomplishments and personality of the sitter, written by another distinguished scientist.

This book portrays, in pencil and prose, 62 outstanding scientists who have had an extraordinary influence on our current understanding of biology, evolution, and medical science. Now, after a lifetime of accomplishment in research, writing, education, and science advocacy, Watson has delved for the first time publicly into his own lineage to chronicle an archetypical American family from before the Civil War to Vietnam. With its portraits of many memorable characters, illustrated with previously unpublished photographs and period documents, Father To Son brilliantly illuminates the fundamental truth that who we become as individuals is determined by both our genetic and cultural heritage.

Fission yeast are unicellular, rod-shaped fungi that divide by medial fission. Studies using fission yeast were instrumental in identifying fundamental mechanisms that govern cell division, differentiation, and epigenetics, to name but a few. Their rapid growth rate, genetic malleability, and similarities to more complex eukaryotes continue to make them excellent subjects for many biochemical, molecular, and cell biological studies. This laboratory manual provides an authoritative collection of core experimental procedures that underpin modern fission yeast research. The contributors describe basic methods for culturing and genetically manipulating fission yeast, synchronization strategies for probing the cell cycle, technologies for assessing proteins, metabolites, and cell wall constituents, imaging methods to visualize subcellular structures and dynamics, and protocols for investigating chromatin and nucleic acid metabolism.

Modifications to techniques commonly used in related species e. The well-studied fission yeast Schizosaccharomyces pombe is the focus throughout, but the emerging model S. This manual is an important reference for existing fission yeast laboratories and will serve as an essential start-up guide for those working with fission yeast for the first time. From unpromising beginnings, he became a vital contributor to a remarkably creative period in science. About the author: Robert Olby, a prominent historian of science, is research professor in the Department of History and Philosophy of Science at the University of Pittsburgh and author of the highly regarded Origins of Mendelism , and The Path to the Double Helix , He has published and lectured widely on 19th and 20th century topics in biology, genetics, and molecular biology.

The cochlea, the mammalian auditory organ, is a spiral-shaped structure in the inner ear that is responsible for hearing. It converts sound vibrations into electrical signals and sends them to the brain with a remarkable temporal precision. Defects in the cellular or molecular components of the cochlea can lead to deafness and other hearing impairments. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine provides a comprehensive review of the complex molecular mechanisms that are responsible for cochlear function and were, for the most part, revealed by the discovery of genes responsible for hearing impairment.

It describes major advances in our understanding of the pathogenic processes underlying various forms of hearing loss and the emergence of treatments for deafness. They also consider the properties of other cochlear components, including the tectorial membrane, the synaptic connections with auditory neurons, and the resident macrophages, as well as the development and evolution of the cochlea as a whole.

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Topics such as hair cell regeneration, otoacoustic emissions, and ototoxicity are also discussed. In addition, the authors examine the epidemiology of hearing loss and emerging, innovative, therapeutic strategies e. We share something very special with every human being, animal, plant, and microscopic creature. What do we share with all living things? The establishment of concentration gradients of these morphogens is vital for developmental patterning, ensuring that distinct differentiated cell types appear in the right place and at the right time in forming tissues.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology explores how morphogen gradients are generated and interpreted during development. Including discussion of the roles of morphogen gradients in various tissues in organisms from yeast to humans, the volume is an indispensable reference for developmental biologists and cell biologists wishing to know how cell fate is determined during embryogenesis. The first chapter describes mechanisms found in bacteria, and two subsequent chapters discuss which of these is most highly exploited in higher organisms.

A final chapter relates these molecular strategies to other enzymatic processes, including those involving kinases, RNA splicing enzymes, proteases, and others. A general theme emerges, one that proposes how a rather restricted set of signals and enzymatic functions has been used in evolution to generate complex life forms of different types.

Watson and Francis Crick in , the world of molecular biology was caught up in a gold rush. As he and an international cast of roguish young colleagues do important research they also compare notes and share complaints on the scarcity of eligible mates. And amid the feverish search for the role of the then still mysterious RNA molecule, Watson's thoughts are seldom far from the supreme object of his desire, an enthralling Swarthmore coed who also happens to be the daughter of Harvard's most eminent biologist.

Part scientific apprenticeship, part sentimental education, Genes, Girls, and Gamow is a penetrating revelation of how great science is accomplished. It is also a charmingly candid account of one young man's full range of ambitions. They educate them about inheritance, diseases, and screening tests, interpret medical histories and test results, and help families cope with diagnoses and make informed medical decisions.

The profession is rapidly evolving and is poised to play an increasingly important role in society as genome sequencing becomes routine clinical practice. This collection from Cold Spring Harbor Perspectives in Medicine captures the current state of genetic counseling and examines the changing roles of genetic counselors in the genomic age.

The contributors discuss the range of genetics-related needs people bring to counselors, existing and emerging technologies for genetic testing, challenges related to the abundance of recent discoveries about genetic diseases, the ways in which genetic counseling is integrated into modern medicine, and the expanding roles of genetic counselors beyond the clinical setting. The current and evolving practices in different couseling subspecialties, including infertility, prenatal care, pediatrics, cardiology, neurology, psychiatry, and cancer, are also covered.

Other topics in the volume include ethical, legal, and social issues e. The volume is therefore an essential read for practicing genetic counselors, as well as all biomedical scientists and health professionals dedicated to using genetic and genomic information to improve the lives of individuals and their families.

Genetic counselors advise patients and families affected by or at risk of genetic disorders. The genetic interests of males and females often diverge; traits favored by one sex can be costly to the other.

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Contributors review multiple examples of sexual antagonism e. Topics such as hermaphroditism and homosexuality are also covered. This volume includes discussion of the evolutionary origins of sexual conflict and its relationship to other evolutionary forces e. It will thus be fascinating reading for all geneticists and biologists who are interested in the evolution of sexual reproduction. This special issue will also include a perspective on the determinants of success of whole genome association testing, A User's Guide to the HapMap Project website, and a poster that has been designed to be an educational resource demonstrating the data used to describe the patterns of human variation.

It combines approachable narrative with extensively tested lab exercises that illustrate key concepts of genome biology in humans, invertebrates, and plants. Nineteen labs, organized into four chapters, engage students with both bioinformatics exercises and in vitro experiments. Each chapter also includes an extensive introduction that provides an historical and conceptual framework.

This modular structure offers many options for enhancing existing courses, starting new courses, or supporting student research projects. The book is complete with advice for instructors, laboratory planning guidelines, recipes for solutions, and answers to student questions. Written by leaders in the field, each chapter focuses on a kingdom, group, or species and offers a unique perspective on the history, the current status, and future of genomics research.

In addition, updates on emerging technologies in DNA sequencing and in gene prediction, as well as direction to relevant public resources, are given. This book serves as a valuable reference and teaching tool for established scientists in the genomics field and as a comprehensive overview for those with more general interests in biology. Hundreds of genomes have been completely sequenced in the past decade, significantly advancing our understanding of genome structure and function. In sexually reproducing organisms, germ cells give rise to gametes and serve as the link between generations.

A key event during germ cell development is the decision to leave mitosis and enter meiosis, leading to the formation of mature eggs and sperm. Germ cell development involves unique gene expression programs and the establishment of epigenetic marks that ensure success during fertilization and embryo development.

Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the biology of germ cells in metazoans. The contributors describe the undifferentiated state of germline stem cells, the triggers for meiotic entry, and the transcriptional and post transcriptional controls during spermatogenesis and oogenesis that lead to the formation of mature gametes.

The expression of sex linked genes and the establishment of genomic imprinting in the germline are also covered. This volume, which includes discussions of gamete recognition proteins, egg activation, and genetic reprogramming following nuclear transfer, is an indispensable reference for cell, molecular, and developmental biologists and anyone wishing to understand the implications of germ cell biology for reproductive technologies. Planet Earth can be a dangerous place for all living creatures, including you.

You can usually escape from erupting volcanoes and floods. You can protect your body from the blazing Sun and freezing snow. The majority of cells in the nervous system are glia. Long thought of as passive bystanders, glial cells are increasingly being appreciated for their active roles in nervous system development, function, and disease. The biological characteristics of glial cells in vertebrate and invertebrate model systems, including those of Drosophila, Caenorhabditis elegans, and zebrafish, are also covered.

The authors also discuss the roles of glia in repair and regeneration, as well as in cancer and neurodegenerative diseases. This volume is therefore a valuable reference for all neurobiologists and biomedical scientists wishing to understand these diverse and dynamic cells. Identified more than years ago by Camillo Golgi, the Golgi is a series of flattened cisternae that acts as a critical sorting and processing station for intracellular traffic. It receives cargo in vesicles exported from the endoplasmic reticulum and then dispatches this to the plasma membrane for secretion or directs it to other organelles, such as endosomes.

The Golgi also plays an important role in carbohydrate metabolism: It is the major site for attachment of sugar moieties to proteins. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology includes contributions that review the current models for Golgi traffic and detail the functions of the cargo carrying machinery, such as the COPI and COPII vesicles, the glycosidases and glycosyltransferases that determine the oligosaccharide composition of the cargo, the various sorting signals, GTPases, and adaptor proteins involved, and the tethers and SNAREs that mediate vesicle fusion and deliver the cargo to the next compartment on the pathway.

The contributors also examine recent insights into Golgi architecture and positioning, and the way the Golgi fragments and regenerates during cell division. This volume, which includes discussions of Golgi bypass mechanisms, the evolution and diversity of the Golgi, and the involvement of Golgi in development and human inherited diseases, serves as a comprehensive reference for all cell biologists interested in this intriguing organelle.

Grounds for Knowledge is an engaging and knowledgeable guide to CSH Laboratory's buildings both historic and new, and to the species of trees that surround them. The superb color photography and detailed maps invite exploration of the newly designated Bungtown Botanical Garden.

She also holds honorary doctorates from the College of Charleston and Illinois Wesleyan University, where she has lectured on the preservation of historic landscapes. Author of Houses for Science a centennial history of Cold Spring Harbor Laboratory, , she also drafted the nomination papers that led to placement of the Laboratory's main campus along Bungtown Road on the National Register of Historic Places, In addition, she authored A Limner's View a sailor's view of world architecture, with "limner" Faith H.

Besides having become a manic "leaf peeper" and aspiring to "bird watcher" in her free time, Liz is an avid photographer, enthusiastic traveler, and happy hostess to those from near and far. Once upon a time you were very, very small. In fact, you were made of just one tiny cell. But the incredible thing about that tiny cell was that all the instructions to make you were hidden inside it.

Development of the heart is a complex process and can lead to serious congenital disease if the process goes awry. This book provides a detailed description of the cell lineages involved in heart development and how their migration and morphogenesis are controlled. It also examines the genetic and environmental bases for congenital heart disease and how model systems are revealing more about the processes involved. Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body.

The abundance, stability, and oxygen-carrying properties of hemoglobin can be altered by genetic mutations.

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  6. More than hemoglobin disorders are known; hemoglobinopathies e. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers all aspects of hemoglobin and its diseases. Contributors examine the structure, expression, and evolution of the globin genes, the assembly of globin subunits into functional forms of hemoglobin, and the numerous variants that result from genetic alterations.

    The pathophysiological consequences of hemoglobin disorders e. This book includes discussions of management and treatment strategies for hemoglobin disorders, such as transfusions, iron-chelating agents, gene therapy, and stem cell transplantation. It is an indispensable reference for biochemists, geneticists, cell and developmental biologists, physiologists, and all who are interested in reducing the medical burden of these common genetic diseases. Despite the availability of an effective vaccine for hepatitis B, hundreds of millions of people worldwide are infected with the hepatitis B virus HBV.

    This virus can cause serious liver damage and cancer in chronically infected patients. The new content includes methods for studying interactions between cellular components, such as microarrays, next-generation sequencing technologies, RNA interference, and epigenetic analysis using DNA methylation techniques and chromatin immunoprecipitation. To make sense of the wealth of data produced by these techniques, a bioinformatics chapter describes the use of analytical tools for comparing sequences of genes and proteins and identifying common expression patterns among sets of genes.

    Molecular Cloning: A Laboratory Manual fills the same niche in the laboratory with information to help both the inexperienced and the advanced user. It has once again established its primacy as the molecular laboratory manual and is likely to be found on lab benches It has a pure-bred ancestry, and the new edition does not disappoint. It includes information panels at the end of each chapter that describe the principles behind the protocols The addition of this information extends Molecular Cloning from an essential laboratory resource into a new realm, one merging the previous prototype with a modern molecular monograph